Biodiversity

Tuesday, May 16, 2006

THE STRUCTURE AND SIGNIFICANCE OF DNA TO OUR LIVES

Deoxyribonucleic acid (DNA) is a nucleic acid (“a complex, high-molecular-weight biochemical macromolecule composed of nucleotide chains that convey genetic information”) (2) that are in the form of a double helix. It is able to replicate itself due to its double helix structure. DNA contains “genetic instructions that specify the biological development of all cellular forms of life” (1). DNA is a long “polymer of nucleotides and it encodes the sequence of the amino acid residues in proteins using the genetic code mostly a triplets code of nucleotides” (1).

The DNA molecule is a chain of nucleotides. Each DNA molecule consists of sugar (deoxyribose-it has five Carbons and three Oxygen), a phosphate and one of five kinds of nucleobases (bases). DNA strands are composed of “nucleotide subunits called polymers” (1). DNA has five kinds of nucleotides which are commonly referred to by the identity of their bases (1). The bases are adenine (A), thymine (T), uracil (U), cytosine (C) and guanine (G). Uracil (U) is found in the DNA when cytosine (C) is chemically degraded”.

DNA is sometimes referred to as a “heredity molecule because it carries genetic propagation (when more DNA is produced from the original strand) of most inherited traits” (1). DNA can be transferred after been replicated from the parent to the offspring during reproduction. Each and every one of us has his or her own unique DNA and we have also inherited our genomes from our parents. A genome of an organism carries the whole hereditary information of an individual that is encoded in the DNA (4). Each individual inherits 23 chromosomes from each parent including the X-chromosome (mitochondrial DNA that we inherit from our mothers and Y-chromosome from our fathers (1).

The way in which the “DNA strands stay associated is determined by complementary pairing” (5). Each base forms hydrogen bonds A bonds with T and G with C. the hydrogen bonds between A to T is a double bond and between G to C is a triple bond. Since DNA is a double stranded helix it can also unfold into two single strands by the process called DNA replication. The two resulting double strands which are identical, each “synthesize a new strand by the process called semiconservative replication (the method in which DNA is replicated in all known cells)" (5).

The DNA molecule is always double stranded when it unfolds another strand is synthesized unless the DNA is mutated (change in genetic material) either chemically or during replication. The way the DNA unfolds it is like unzipping a zip of a jersey or any zip. DNA contains the genetic information that is inherited by the offspring and the way the base pairs are paired it determines how the offspring is going to be like. The way the base are determined tells whether the offspring is going to inherit what types of features from which parent. A DNA strands contain genes and areas where gene regulation takes place. Genes can be viewed as a “cookbook or blueprint” (3).

The significance of DNA to us as human beings is that we are able to trace back our ancestors for example scientists used DNA in order to try to find the missing link between “Ape to Man” and to the eight daughters of African Eve. Scientists used DNA in order to trace African Eve eight daughters so DNA is so important. DNA contains genes that parents pass on to their children so the generations can continue. Each and everyone of us has his or her own unique DNA so forensics can solve a crime easily using DNA and some people use it if they want to prove paternity to check if the childs DNA corresponds with the fathers. The problem with DNA is when it is mutated and the body cannot fix or "see" the mutated bases. The person who has mutated base pairs can either be physical deformed or mentally disturbed. For example if people who share the same genes (i.e. father and daughter) mate, the offspring will have no different genes, will have almost the same genes. Since the daughter would have inherited half of the genes from her father and want kind of a child are they going to have? Their child is going to have shared some of the genes with the daughter since they share the same father.

Reference:

1. Wikipedia contributors. DNA [Internet]. Wikipedia, The Free Encyclopedia; 2006 May 01, 23:16. UTC [cited 2006 May 3]. Available from: http://en.wikipedia.org/wiki/DNA
2. Wikipedia contributors. Nucleic acid [Internet]. Wikipedia, The Free Encyclopedia; 2006 May 01, 12:48. UTC [cited 2006 May 3]. Available from: http://en.wikipedia.org/wiki/Nucleic_acid
3. Wikipedia contributors. DNA replication [Internet]. Wikipedia, The Free Encyclopedia; 2006 May 2, 04:25 UTC [cited 2006 May 3]. Available from: http://en.wikipedia.org/wiki/DNA_replication
4. Wikipedia contributors. Genomes [Internet]. Wikipedia, The Free Encyclopedia; 2006 May 3, 04:39 UTC [cited 2006 May 3]. Available from: http://en.wikipedia.org/wiki/Genomes
5. Wikipedia contributors. Semiconservative replication [Internet]. Wikipedia, The Free Encyclopedia; 2006 Feb 3, 04:39 UTC [cited 2006 May 3]. Available from: http://en.wikipedia.org/wiki/Semiconservative_replication

Lethabo Mosomane
CSIR
Pretoria
0001
Tel: 27 12 841 2133
Fax: 27 12 842 3676
mail: lmosomane@csir.co.za
http://lmosomane.blogspot.com/

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